Depakote Side Effects
Headaches, drowsiness, shakiness, and nausea are among the most frequently reported Depakote mood stabilizer side effects. Side effects associated with this anticonvulsant mood stabilizer less frequently but are possibly serious include worsening of seizures, depression, and unexplained bleeding or bruising.

Any side effects should be reported to your healthcare provider, whether they are commonly reported headaches or rare side effects like unexplained bleeding/bruising. In clinical studies, shakiness or tremors were found to occur in up to 57% of Depakote users, nausea in up to 48% of, headaches in up to 31%; drowsiness in up to 30%, weakness in up to 27%, vomiting in up to 27%, and dizziness was reported in up to 25% of individuals taking the drug.
Other common Depakote side effects, found to occur in anywhere from 5% to 24% of users, include: hair loss, coordination difficulties, loss of appetite or increased appetite, weight loss, weight gain, back pain, infections, heartburn or indigestion, uncontrollable eye movements, constipation or diarrhea, stomach pain (or abdominal pain), nervousness, double vision, blurred vision, insomnia, flu-like symptoms such as fever or chills; tinnitus (ringing in the ears), fever, amnesia or memory loss, emotional problems, and swelling in the feet, arms, or legs.
Serious Depakote mood stabilizer antipsychotic side effects include but are not limited to: signs of pancreatitis (inflamed pancreas), such as vomiting and nausea, loss of appetite, and severe stomach pain (or abdominal pain); signs of liver damage, such as jaundice (yellow skin or eyes); depression, worsening of seizures; suicidal thoughts or behaviors; hypothermia (low body temperature under 95 degrees F), unexplained bleeding or bruising, and signs of an allergic reaction, such as unexplained swelling, an unexplained rash, hives, and itching. Individuals are usually prescribed these medications after having psychotic breaks or when other drugs have not worked, and often without any investigation into the reasons why the person experiences psychosis.
It is possible that some individuals who take this drug may never notice any side effects, however there are plenty of individuals who do encounter plenty of Depakote side effects and sometimes such side effects can be more apparent than the therapeutic purpose of the drug. There is no way for healthcare providers to know beforehand if a patient will experience Depakote side effects. Therefore, individuals often endure exhausting trial and error processes trying to find a medication with tolerable side effects. Mood stabilizer side effects may be eliminated by using alternative ways of treatment. Individuals who suffer with Depakote mood stabilizer side effects may find relief in alternative treatments; ask your healthcare provider about alternatives to mood stabilizers.
At Alternative to Meds Center, we discover the real medical reasons that are underlying an individual’s depression, mania or mood swings. This answer is specifically different for each person, but usually the problem is an excess of Dopamine; the neurochemical of “reward”. An excess of Dopamine makes everything too stimulating and often results in manic episodes. The drug then restricts Dopamine, and leaves the person without being able to enjoy life’s rewards. When Dopamine is inhibited from the use of a prescription drug, the brain is altered in the Synapse. The synapse is the location where one nerve communicates with the next nerve, and Dopamine is what excites that impulse of the first nerve over to the receptors of the next nerve. At this point, the little amount of Dopamine produces the same over-stimulating effect even with presence of the drug. Therefore, the dosage is increased and it brings on more mood stabilizer side effects.
For effective withdrawal from these medications we employ the following measures. We first do lab testing for what might have cause the originating issues, usually finding toxicity as the problem. We then work to clear the person of toxins. Our program is focused at neurochemistry stabilization with natural substances, cessation of toxins accumulated environmentally, targeted nutritional support, peer support, IV amino therapies, yoga, personal exercise training, massage, and other healing therapies designed to address withdrawal side effects. When the person starts to experience the sedation and stability of these therapies, their medication is slowly reduced and adjusted as needed.
Learn more about the underlying reasons why mood stabilizers are prescribed and how we may help you to stop suffering from Depakote withdrawal side effects.